Pharmacometabolomics in Early‐Phase Clinical Development

Pharmacometabolomics in Early‐Phase Clinical Development

Pharmacometabolomics in Drug Discovery & Development: Applications and Challenges

Volume 2 • Issue 5 • 1000e122 prevention, early detection, and monitoring the progression of diseases [13,14]. With high throughput/high resolution mass spectrometry and NMR techniques as well as various statistical models, many biomarkers in human disease were successfully identified to differentiate patients and health control groups, or to predict death [15]. It is very critical for the phar...

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اشعار ریچ، به عنوان اشعاری که همیشه در حال تغییر و دگرگونی هستند، تجسمی از رشد و دگرگونیِ انسان هستد. پایان نامه ی حاضر، با تمرکز بر روی مراحل سیر شعری ریچ از تغییری در دنیا به عکس هایی فوری از یک عروس، سپس به شیرجه به درون کشتی شکسته و در نهایت به صبری عجیب مرا تا اینجا آورده، به بررسی این مراحل در قالب نظر شوالتر در رابطه با سه مرحله ی پیشرفت ادبی زنان یعنی مرحله ی زنانه، زن گرا و زن محور می پ...

Pharmacometabolomics-aided Pharmacogenomics in Autoimmune Disease.

Inter-individual variability has been a major hurdle to optimize disease management. Precision medicine holds promise for improving health and healthcare via tailor-made therapeutic strategies. Herein, we outline the paradigm of "pharmacometabolomics-aided pharmacogenomics" in autoimmune diseases. We envisage merging pharmacometabolomic and pharmacogenomic data (to address the interplay of geno...

Pharmacometabolomics Informs Viromics toward Precision Medicine

Nowadays, we are experiencing the big data era with the emerging challenge of single data interpretation. Although the advent of high-throughput technologies as well as chemo- and bio-informatics tools presents pan-omics data as the way forward to precision medicine, personalized health care and tailored-made therapeutics can be only envisaged when interindividual variability in response to/tox...